Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens

SS Schatzman, RL Peterson, M Teka, B He… - Journal of Biological …, 2020 - ASBMB
… Conversely, SOD4 expression was specifically up-regulated by iron (Fe) starvation and …
fungi, this SOD was induced by Fe starvation. This unexpected link between Fe homeostasis and …

Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones

D Anabosi, Z Meir, Y Shadkchan, M Handelman… - Virulence, 2021 - Taylor & Francis
… AtxA expression increased under iron starvation irrespective of Cu levels, indicating a …
chaperones Cu to the Cu/Zn superoxide dismutase Sod1p, and ccs1 deletion leads to sensitivity to …

At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin

AM Traynor, RA Owens, CM Coughlin… - …, 2021 - microbiologyresearch.org
… Later, the observed increased expression of genes involved in zinc … [40] revealed that iron
starvation increases zinc toxicity and … fumigatus [45], is either produced at high zinc due to an …

Superoxide dismutases in eukaryotic microorganisms: four case studies

A de Obeso Fernandez del Valle, CQ Scheckhuber - Antioxidants, 2022 - mdpi.com
… of the genus Aspergillus that can potentially cause aspergillosis; the … analysis, that iron
deprivation increases oxidative stress … , SODs serve as starvation signals that are causative of the …

Fungal–metal interactions: A review of toxicity and homeostasis

JR Robinson, OS Isikhuemhen, FN Anike - Journal of Fungi, 2021 - mdpi.com
… grey mold disease caused by Aspergillus niger, Fusarium … copper is the cytoplasmic Cu/Zn
superoxide dismutase (Sod1)… Its effects on increased iron resistance and storage capacity …

[HTML][HTML] Ambient availability of amino acids, proteins, and iron impacts copper resistance of Aspergillus fumigatus

A Yap, H Talasz, H Lindner, R Würzner… - Frontiers in Cellular and …, 2022 - frontiersin.org
starvation increased copper susceptibility, which underlines the importance of cellular metal
balancing. Due to the role of iron … a higher crpA expression during Fe starvation compared to …

Zinc Starvation Induces Cell Wall Remodeling and Activates the Antioxidant Defense System in Fonsecaea pedrosoi

TAO Santos, LW Soares, LN Oliveira, D Moraes… - Journal of Fungi, 2024 - mdpi.com
… pathogens Candida albicans, Aspergillus fumigatus, and … and without the supplementation
of 100 μM of iron ((NH 4 ) 2 Fe(… By contrast, Cu/Zn superoxide dismutase was downregulated…

Oxidative Stress Causes Vacuolar Fragmentation in the Human Fungal Pathogen Cryptococcus neoformans

D Kim, M Song, E Do, Y Choi, JW Kronstad, WH Jung - Journal of Fungi, 2021 - mdpi.com
Aspergillus and Candida, suggesting that Sod2 is the major SOD and is significantly influenced
by iron … We hypothesize that increased superoxide due to lack of Sod2 may also cause a …

[PDF][PDF] ROLE OF GENETIC, EPIGENETIC AND STRESS ADAPTATION FACTOR IN VIRULENCE OF Aspergillus-AN UNTOLD STORY

B DATT, N AKHTAR, M MANNAN - … CELL BIOTECHNOLOGY AND …, 2021 - researchgate.net
… a variety of enzymes like Cu/Zn superoxide dismutase (SOD), … ) are expressed in a Mac1
dependent manner in a Cu starvation … A copper transcription factor, AfMac1, regulates both iron

The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans

AS Wildeman, NK Patel, BP Cormack… - PLoS …, 2023 - journals.plos.org
… During infection, the mammalian host attempts to starve … have been linked to Cd resistance,
and in the Aspergillus orzyae … -anchor protein that is abundantly expressed in the cell wall of …